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Year Number of Results
1999 2
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2008 4
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2010 4
2011 4
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2014 9
2015 7
2016 5
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84 results

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Hypoxia-induced up-regulation of VASP promotes invasiveness and metastasis of hepatocellular carcinoma.
Liu Z, Wang Y, Dou C, Xu M, Sun L, Wang L, Yao B, Li Q, Yang W, Tu K, Liu Q. Liu Z, et al. Theranostics. 2018 Sep 9;8(17):4649-4663. doi: 10.7150/thno.26789. eCollection 2018. Theranostics. 2018. PMID: 30279729 Free PMC article.
We investigated the positive correlation between VASP and an adapter protein, CRKL. VASP dynamically co-localized at the SH3N domain of CRKL and mediated its function. Mechanistically, VASP overexpression at the transcriptional level was mediated by HIF-1alph …
We investigated the positive correlation between VASP and an adapter protein, CRKL. VASP dynamically co-localized at the SH3N …
Podocyte protease activated receptor 1 stimulation in mice produces focal segmental glomerulosclerosis mirroring human disease signaling events.
May CJ, Chesor M, Hunter SE, Hayes B, Barr R, Roberts T, Barrington FA, Farmer L, Ni L, Jackson M, Snethen H, Tavakolidakhrabadi N, Goldstone M, Gilbert R, Beesley M, Lennon R, Foster R, Coward R, Welsh GI, Saleem MA. May CJ, et al. Kidney Int. 2023 Aug;104(2):265-278. doi: 10.1016/j.kint.2023.02.031. Epub 2023 Mar 20. Kidney Int. 2023. PMID: 36940798 Free article.
About 30% of patients who have a kidney transplant with underlying nephrotic syndrome (NS) experience rapid relapse of disease in their new graft. This is speculated to be due to a host-derived circulating factor acting on podocytes, the target cells in the kidney, leading …
About 30% of patients who have a kidney transplant with underlying nephrotic syndrome (NS) experience rapid relapse of disease in the …
VASP regulates leukocyte infiltration, polarization, and vascular repair after ischemia.
Laban H, Weigert A, Zink J, Elgheznawy A, Schürmann C, Günther L, Abdel Malik R, Bothur S, Wingert S, Bremer R, Rieger MA, Brüne B, Brandes RP, Fleming I, Benz PM. Laban H, et al. J Cell Biol. 2018 Apr 2;217(4):1503-1519. doi: 10.1083/jcb.201702048. Epub 2018 Mar 5. J Cell Biol. 2018. PMID: 29507126 Free PMC article.
Importantly, VASP deletion in bone marrow-derived cells was sufficient to mimic the increased blood flow recovery of global VASP(-/-) mice. ...Mechanistically, VASP formed complexes with the chemokine receptor CCR2 and beta-arrestin-2, and CCR2 receptor inter …
Importantly, VASP deletion in bone marrow-derived cells was sufficient to mimic the increased blood flow recovery of global VASP …
CREB1/Lin28/miR-638/VASP Interactive Network Drives the Development of Breast Cancer.
Hu PC, Li K, Tian YH, Pan WT, Wang Y, Xu XL, He YQ, Gao Y, Wei L, Zhang JW. Hu PC, et al. Int J Biol Sci. 2019 Oct 21;15(12):2733-2749. doi: 10.7150/ijbs.36854. eCollection 2019. Int J Biol Sci. 2019. PMID: 31754343 Free PMC article.
In this study, we find that miR-638 can target to inhibit VASP expression, and Lin28 acts as an RNA-binding protein to regulate the processing of miR-638, which inhibits its maturation and promotes the expression of VASP. In addition, we also find that CREB1 acts as …
In this study, we find that miR-638 can target to inhibit VASP expression, and Lin28 acts as an RNA-binding protein to regulate the p …
Novel Regulators of Retina Neovascularization: A Proteomics Approach.
Xu M, Jiang Y, Su L, Chen X, Shao X, Ea V, Shang Z, Zhang X, Barnstable CJ, Li X, Tombran-Tink J. Xu M, et al. J Proteome Res. 2022 Jan 7;21(1):101-117. doi: 10.1021/acs.jproteome.1c00547. Epub 2021 Dec 17. J Proteome Res. 2022. PMID: 34919406 Free article.
These proteins control angiogenesis-related processes including matrix remodeling, cell migration, adhesion, and proliferation. RNAi and transfection overexpression studies confirmed that VASP and ECH1, showing the highest levels in hypoxic HRECs, promoted human umbilical …
These proteins control angiogenesis-related processes including matrix remodeling, cell migration, adhesion, and proliferation. RNAi and tra …
Phosphorylation of vasodilator-stimulated phosphoprotein contributes to myocardial ischemic preconditioning.
Köhler D, Bibli SI, Klammer LP, Roth JM, Lehmann R, Fleming I, Granja TF, Straub A, Benz PM, Rosenberger P. Köhler D, et al. Basic Res Cardiol. 2018 Jan 17;113(2):11. doi: 10.1007/s00395-018-0667-0. Basic Res Cardiol. 2018. PMID: 29344719
Yet, the role of VASP during myocardial IP is, to date, not known. We report here that VASP phosphorylation at serine(157) and serine(239) is induced during hypoxia in vitro and during IP in vivo. ...Experiments in chimeric mice confirmed the importance of VASP …
Yet, the role of VASP during myocardial IP is, to date, not known. We report here that VASP phosphorylation at serine(157) and …
Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion.
Damiano-Guercio J, Kurzawa L, Mueller J, Dimchev G, Schaks M, Nemethova M, Pokrant T, Brühmann S, Linkner J, Blanchoin L, Sixt M, Rottner K, Faix J. Damiano-Guercio J, et al. Elife. 2020 May 11;9:e55351. doi: 10.7554/eLife.55351. Elife. 2020. PMID: 32391788 Free PMC article.
Ena/VASP-deficiency also impaired integrin-mediated adhesion accompanied by reduced traction forces exerted through these structures. Our data thus uncover novel Ena/VASP functions of these actin polymerases that are fully consistent with their promotion of cell mig …
Ena/VASP-deficiency also impaired integrin-mediated adhesion accompanied by reduced traction forces exerted through these structures. …
Hypertension alters phosphorylation of VASP in brain endothelial cells.
Arlier Z, Basar M, Kocamaz E, Kiraz K, Tanriover G, Kocer G, Arlier S, Giray S, Nasırcılar S, Gunduz F, Senturk UK, Demir N. Arlier Z, et al. Int J Neurosci. 2015 Apr;125(4):288-97. doi: 10.3109/00207454.2014.930740. Epub 2014 Jul 3. Int J Neurosci. 2015. PMID: 24894047
VASP regulation of endothelial barrier function has been demonstrated by studies using VASP(-/-) animals under conditions associated with tissue hypoxia. ...Exercise reversed hypertension-induced alterations in VASP phosphorylation. Western blotting and immun …
VASP regulation of endothelial barrier function has been demonstrated by studies using VASP(-/-) animals under conditions asso …
Metabolic regulation of intestinal epithelial barrier during inflammation.
Colgan SP, Curtis VF, Lanis JM, Glover LE. Colgan SP, et al. Tissue Barriers. 2015 Apr 3;3(1-2):e970936. doi: 10.4161/21688362.2014.970936. eCollection 2015. Tissue Barriers. 2015. PMID: 25838978 Free PMC article.
Studies from cultured cell systems, animal models and human patients have revealed that metabolites generated within the inflammatory microenvironment are central to barrier regulation. These studies have revealed a prominent role for hypoxia and hypoxia-inducible f …
Studies from cultured cell systems, animal models and human patients have revealed that metabolites generated within the infla …
Improved Endothelium-Dependent Relaxation of Thoracic Aorta in Niclosamide-Treated Diabetic Rats.
Engin S, Yasar YK, Barut EN, Sezen SF. Engin S, et al. Cardiovasc Toxicol. 2021 Jul;21(7):563-571. doi: 10.1007/s12012-021-09647-0. Epub 2021 Mar 27. Cardiovasc Toxicol. 2021. PMID: 33772737
The changes in the protein expressions of phosphorylated eNOS at serine 1177 (p-eNOS(Ser1177)) and phosphorylated VASP at serine 239 (p-VASP(Ser239)) of the rat aortas were analyzed by western blotting to determine whether NO/cGMP signaling is involved in the mechan …
The changes in the protein expressions of phosphorylated eNOS at serine 1177 (p-eNOS(Ser1177)) and phosphorylated VASP at serine 239 …
84 results